Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Department of Neurology and Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Pediatr Blood Cancer. 2021 Jun;68(6):e29000. doi: 10.1002/pbc.29000. Epub 2021 Apr 5.
Choriocarcinoma syndrome is an uncommon, potentially fatal complication of germ cell tumors (GCTs) in adults, but it is not well documented in children. Pediatric central nervous system (CNS) GCTs comprise a rare group of malignancies not usually associated with extra-CNS metastatic disease. Here, we report the case of a pediatric patient with a suprasellar mixed GCT and pulmonary metastases who presented with intratumoral hemorrhage and stroke. Choriocarcinoma syndrome developed soon after initiating chemotherapy. The primary tumor and pulmonary metastases were successfully treated using a multidisciplinary approach, including neurovascular intervention, chemotherapy, and craniospinal irradiation.
绒癌综合征是一种罕见的、可能致命的成人生殖细胞肿瘤（GCT）并发症，但在儿童中记录并不充分。儿童中枢神经系统（CNS）GCT 是一组罕见的恶性肿瘤，通常与中枢神经系统外转移疾病无关。在此，我们报告了一例鞍上混合 GCT 和肺转移的儿科患者，该患者因肿瘤内出血和中风而就诊。绒癌综合征在开始化疗后很快就出现了。通过多学科方法，包括神经血管介入、化疗和颅脊髓照射，成功治疗了原发肿瘤和肺转移。
