Dohy H, Kyo T
Dept. of Internal Medicine, Hiroshima Red Cross Hospital.
Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-2):1223-8.
It has been proposed that intensive chemotherapy ror RAEB is dangerous, and a small dose of ara-C therapy is recommended in many institutes for its ability to differentiate leukemic cells. Combination chemotherapy for RAEB, however, has not been completely evaluated. We introduced B-DOMP therapy, which is used in our hospital, for RAEB. B-DOMP therapy includes Behenoyl ara-C, daunomycin, oncovin, 6-MP and prednisolone, which achieved approximately 80% of complete remission of ANLL for adults. Five males and one female of RAEB, aged 40-74 (median 70), were treated by B-DOMP regimen. Two cases achieved complete remission, 2 remained in partial remission and 2 cases died within one month. In three cases, the cause of death was fungal pneumonia. It must be stressed that life-threatening pneumonia was common after chemo therapy for RAEB, and careful protection against fungal infection using laminarair flow is required.
有人提出，对难治性贫血伴原始细胞增多（RAEB）进行强化化疗是危险的，许多机构推荐小剂量阿糖胞苷疗法，因为它有使白血病细胞分化的能力。然而，针对RAEB的联合化疗尚未得到全面评估。我们引入了本院使用的B-DOMP疗法来治疗RAEB。B-DOMP疗法包括山嵛酰阿糖胞苷、柔红霉素、长春新碱、6-巯基嘌呤和泼尼松龙，该疗法使成人急性非淋巴细胞白血病（ANLL）的完全缓解率达到了约80%。6例RAEB患者（5男1女），年龄40 - 74岁（中位数70岁），接受了B-DOMP方案治疗。2例达到完全缓解，2例仍为部分缓解，2例在1个月内死亡。3例的死因是真菌性肺炎。必须强调的是，RAEB化疗后危及生命的肺炎很常见，需要使用层流空气仔细预防真菌感染。
