Nishiya I, Kagabu T, Satoh K
Dept. of Obstetrics and Gynecology, Iwate Medical University.
Gan To Kagaku Ryoho. 1988 Jun;15(6):1847-54.
The relative incidence of endometrial carcinoma is obviously increasing as a disease of post-menopausal women with the ageing of the population in Japan. Growth of malignant endometrium tends to develop there both into the muscle and into the cavity. However, diagnosis in most cases is made by stage 1a (39.7%) and 1 b (19.0%) in FIGO classification. In the treatment of endometrial carcinoma, even after a simple hysterectomy in 89.2% of total cases 5-year cure rate may be reached to 80%, which has compared well with the 60% cure rate for cervical cancer. Some fractions of endometrial adenocarcinoma are estrogen-dependent and could therefore respond to antagonistic influences of progestogens. In a recent understanding, above theoretical grounds for hormone dependency and responsiveness of endometrial malignant lesions has been substantiated by data provided by steroid receptor determination. The high estrogen and progesterone receptor concentrations found in 70% of endometrial adenocarcinoma support the principle that endometrial adenocarcinoma is related to abnormal estrogenic stimulation. Those cancer are used as a model for in vitro and clinical evaluation of progestogen therapy.
随着日本人口老龄化，子宫内膜癌作为绝经后女性的一种疾病，其相对发病率明显上升。恶性子宫内膜的生长往往会向肌层和宫腔发展。然而，在大多数病例中，根据国际妇产科联盟（FIGO）分类，诊断时处于1a期（39.7%）和1b期（19.0%）。在子宫内膜癌的治疗中，即使在89.2%的病例中仅进行了简单的子宫切除术，5年治愈率仍可达到80%，这与宫颈癌60%的治愈率相比效果良好。部分子宫内膜腺癌依赖雌激素，因此可能对孕激素的拮抗作用有反应。最近的认识是，子宫内膜恶性病变的激素依赖性和反应性的上述理论依据已通过甾体受体测定提供的数据得到证实。在70%的子宫内膜腺癌中发现的高雌激素和孕激素受体浓度支持了子宫内膜腺癌与异常雌激素刺激有关的观点。这些癌症被用作孕激素治疗的体外和临床评估模型。
