药用蘑菇在骨质疏松症预防和治疗中的应用（综述）。

Medicinal Mushrooms for Prevention and Therapy of Osteoporosis (Review).

机构信息

Institute of Pharmacy, Pharmaceutical Biology, University of Greifswald, Institute of Pharmacy, Ernst-Moritz-Arndt University of Greifswald, Friedrich-Ludwig-Jahn Str. 17, D-17489 Greifswald, Germany.

出版信息

Int J Med Mushrooms. 2021;23(4):13-22. doi: 10.1615/IntJMedMushrooms.2021038084.

DOI:10.1615/IntJMedMushrooms.2021038084

PMID:33822504

Abstract

Osteoporosis is an important public health challenge. Several medicinal mushrooms are able to improve bone stability by influencing different steps of bone formation, mineralization, or resorption. In nearly all investigations, the effects have been shown in vitro or in animal assays and only very few in clinical studies. Positive results exist for medicinal mushrooms of the genera Cordyceps/Ophiocordyceps, Ganoderma, Grifola, Lentinula, Phellinus, Pleurotus, Taiwanofungus, Trametes, and Wolfiporia. The results for Hericium are not consistent. This article critically reviews these investigations and describes challenges for the future.

摘要

骨质疏松症是一个重要的公共健康挑战。几种药用蘑菇能够通过影响骨形成、矿化或吸收的不同步骤来提高骨骼稳定性。在几乎所有的研究中，这些作用都已经在体外或动物实验中得到了证实，而在临床研究中则非常少。在属虫草、灵芝、灰树花、香菇、木蹄层孔菌、平菇、台湾拟层孔菌、云芝和松口蘑的药用蘑菇中已经有了阳性结果。对于珊瑚菌的结果则不一致。本文批判性地回顾了这些研究，并描述了未来的挑战。