Genetically engineered T-cell therapies have the adeptness to modernize and revolutionize the treatment of cancer. Cancer immunotherapy, by depending on this fundamental recognition method, supports the antitumor viability of T cells and extends adaptive immunity by encouraging adoptive transfer of genetically engineered T cells. T cells assume a key part in cell-mediated immunity as well as to make strategies for genetically modify T cells, counting chimeric antigen receptor (CAR) T-cell therapy and T-cell receptor (TCR) T-cell therapy. They have accomplished significant advances in the treatment of neoplastic diseases. Tumor cells can produce neoantigens that can possibly be immunogenic, as mutated proteins or proteins with reformed translational processing can be viewed as unfamiliar or foreign by immune system. Recognizable human tumor antigens have prompted a superior understanding the idea of tumor antigens, anti-tumor immune reactions in immunotherapeutic patients as well as tumor escape mechanisms. Furthermore, paucity of exceptionally and homogeneously expressed tumor antigens and intrinsic plasticity of neoplastic cells provide key challenges to specificity, effectiveness, and generally adequacy of genetically engineered T-cell therapies. Difficulties ranges from the determination of antigen targets and managing regulatory and safety issues to effectively explore routes to commercial advancement. In any case, the empowering clinical information, advancement in scientific understanding of tumor immunology along with improvements in manufacture of cell products are altogether propelling the clinical interpretation of modern cancer immunotherapies. In this review, we sum up the advancement of genetically engineered T cells, tumor antigen with intrigue the most recent investigation regarding genetically engineered T cells for cancer immunotherapy, and to confer strategies for refining enactment of these T cells to combat cancers.