Ward M M
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor.
Arch Intern Med. 1988 Jul;148(7):1553-7.
In a historical cohort study, acute renal failure developed in 16.5% of 157 patients with rhabdomyolysis over a two-year study period. Underlying clinical, laboratory, and causative factors associated with the development of acute renal failure were examined. Factors predictive of renal failure in this setting, determined by multiple logistic regression analysis, included the degree of serum creatine kinase, serum potassium, and serum phosphorus level elevation; the degree of depression of serum albumin level; and the presence of dehydration at presentation or sepsis as the underlying cause. The predictive model that was developed correctly classified 93% of subjects and was statistically validated.
在一项历史性队列研究中，157例横纹肌溶解症患者在两年的研究期间内，16.5%发生了急性肾衰竭。对与急性肾衰竭发生相关的潜在临床、实验室及病因学因素进行了检查。通过多因素逻辑回归分析确定，在此种情况下预测肾衰竭的因素包括血清肌酸激酶、血清钾和血清磷水平升高的程度；血清白蛋白水平降低的程度；以及就诊时存在脱水或潜在病因是脓毒症。所建立的预测模型对93%的受试者进行了正确分类，并经过了统计学验证。
