Pfefferbaum A, Zipursky R B, Lim K O, Zatz L M, Stahl S M, Jernigan T L
Department of Psychiatry, Stanford University School of Medicine, Calif.
Arch Gen Psychiatry. 1988 Jul;45(7):633-40. doi: 10.1001/archpsyc.1988.01800310037005.
Quantification of ventricular and sulcal volumes from the computed tomographic (CT) scans of 45 schizophrenic patients and 57 normal controls was carried out using a semi-automated computerized approach. The sizes of all cerebrospinal fluid spaces measured were significantly related to age in the control population. An age regression model was used to compare patients and controls. Schizophrenics had slightly larger ventricles and considerably larger sulci than controls. Enlargement of the ventricles and sulci was not correlated with measures of negative symptoms or neuropsychological impairment. The CT scans of eight very ill chronically institutionalized schizophrenics were also analyzed. Their CT findings did not differ significantly from the larger group of schizophrenics studied. Our results show that the cerebral atrophy found in schizophrenia is diffuse in nature and does not relate clearly to measures of disease severity or chronicity.
采用半自动计算机化方法，对45例精神分裂症患者和57名正常对照者的计算机断层扫描（CT）图像进行脑室和脑沟容积定量分析。在正常人群中，所测量的所有脑脊液间隙大小均与年龄显著相关。采用年龄回归模型对患者和对照者进行比较。精神分裂症患者的脑室略大于对照组，脑沟则明显大于对照组。脑室和脑沟扩大与阴性症状或神经心理损害指标无关。还对8例长期住院的重症精神分裂症患者的CT扫描图像进行了分析。他们的CT检查结果与较大样本的精神分裂症患者组相比无显著差异。我们的研究结果表明，精神分裂症患者大脑萎缩具有弥漫性，与疾病严重程度或病程指标无明显关联。
