Jernigan T L, Zatz L M, Moses J A, Berger P A
Arch Gen Psychiatry. 1982 Jul;39(7):765-70. doi: 10.1001/archpsyc.1982.04290070001001.
Recent findings of enlarged ventricles and sulcal widening in the computed tomographic (CT) scans of schizophrenic subjects have raised questions about the etiology and treatment of this disorder. Measures obtained from computerized analyses of CT scans of 30 schizophrenic and 33 normal subjects showed no significant difference between the groups in ventricular or sulcal fluid volumes. The discrepancy between our findings and those of other investigators may have been due to different measurement techniques or to differences in the samples. A second study was undertaken to examine the first possibility. Its results suggest that our findings and those based on measurements of planimetric ventricle-brain ratios (VBRs) are highly correlated, but that VBRs from one study may not be compared with those in another to establish population differences. Differences in patient samples appear to constitute an important source of discrepancy in CT findings.
近期对精神分裂症患者计算机断层扫描（CT）的研究发现脑室扩大和脑沟增宽，这引发了对该疾病病因及治疗的质疑。对30名精神分裂症患者和33名正常人的CT扫描进行计算机分析得出的测量结果显示，两组在脑室或脑沟液体量方面无显著差异。我们的研究结果与其他研究者的差异可能是由于测量技术不同或样本差异所致。开展了第二项研究以检验第一种可能性。其结果表明，我们的研究结果与基于平面脑室-脑比率（VBR）测量结果高度相关，但一项研究中的VBR不能与另一项研究中的VBR进行比较以确定人群差异。患者样本的差异似乎是CT检查结果差异的一个重要来源。
