Department of Child and Adolescent Psychiatry, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
Department of Child and Adolescent Psychiatry, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Int J Psychiatry Clin Pract. 2022 Mar;26(1):8-13. doi: 10.1080/13651501.2021.1906906. Epub 2021 Apr 6.
To compare vitamin B12, homocysteine, and anti-parietal cell antibody (APCA) levels between children with ASD and controls, paired in terms of age, sex, and socioeconomic level.
The research group consisted of 69 children, 36 with ASD and 33 controls. The severity of ASD was determined using the Childhood Autism Rating Scale (CARS). Serum vitamin B12, homocysteine and human anti-parietal cell levels were analysed using enzyme-linked immunosorbent assay.
The serum vitamin B12 and homocysteine levels in children with ASD were lower than in the control group, but there was no significant difference in terms of APCA levels.
Deficiencies in micronutrients, such as B12, may play a role in the pathogenesis and clinical symptoms of autism. However, it is believed that these parameters should be analysed in a wider population to clarify their effect on the aetiology of ASD.KEY POINTWe hypothesised that low levels of vitamin B12 and homocysteine levels reported in previous studies might be associated with APCA levels.The homocysteine and B12 levels were found to be significantly lower in children with ASD. There was no significant difference in serum APCA levels.No significant relationship was found between B12 levels and APCA.Given all these findings, it can be stated that vitamin B12 deficiency is not associated with an absorption-related mechanism due to the presence of APCA.Deficiencies in micronutrients, such as B12, may play a role in the pathogenesis and clinical symptoms of autism.In future studies, it will be beneficial to investigate other mechanisms that may cause vitamin B12 deficiency.
比较自闭症谱系障碍（ASD）儿童与对照组儿童的维生素 B12、同型半胱氨酸和壁细胞抗体（APCA）水平，两组在年龄、性别和社会经济水平方面相匹配。
研究组包括 69 名儿童，36 名 ASD 儿童和 33 名对照组儿童。使用儿童自闭症评定量表（CARS）评估 ASD 严重程度。采用酶联免疫吸附试验分析血清维生素 B12、同型半胱氨酸和人抗壁细胞水平。
ASD 儿童的血清维生素 B12 和同型半胱氨酸水平低于对照组，但 APCA 水平无显著差异。
微量营养素（如 B12）缺乏可能在自闭症的发病机制和临床症状中起作用。然而，据信这些参数应该在更广泛的人群中进行分析，以阐明它们对 ASD 病因的影响。
我们假设之前研究报告的低维生素 B12 和同型半胱氨酸水平可能与 APCA 水平有关。
研究发现 ASD 儿童的同型半胱氨酸和 B12 水平明显较低。血清 APCA 水平无显著差异。
B12 水平与 APCA 之间无显著相关性。
鉴于所有这些发现，可以得出结论，维生素 B12 缺乏与由于存在 APCA 而导致的吸收相关机制无关。
微量营养素（如 B12）缺乏可能在自闭症的发病机制和临床症状中起作用。
在未来的研究中，研究可能导致维生素 B12 缺乏的其他机制将是有益的。
