State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China | University of Chinese Academy of Sciences, Beijing, 100049, China | Nantong Chanyoo Pharmatech Co., Ltd., Nantong 226407, China.
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization and Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China | University of Chinese Academy of Sciences, Beijing, 100049, China.
Mini Rev Med Chem. 2021;21(20):3203-3218. doi: 10.2174/1389557521666210325120233.
The small-molecular inhibitors targeted JAks (JAK inhibitors) could modulate the cytokines- mediated signaling via the JAK-STAT pathway, which plays an important role in immune regulation and cell proliferation. The JAK inhibitors were previously designed and synthesized to treat diseases involving the hematologic and immune system. Increasing evidence shows that they are quite effective in Atopic Dermatitis (AD), Alopecia Areata (AA), psoriasis, vitiligo, and other autoimmuneinduced dermatologic conditions. Currently, many JAK inhibitors possessing anti-vitiligo activity are being investigated in the laboratory and clinically. In this view, we would like to summarize the applications of these inhibitors with emphasis on the profile of vitiligo, clinical efficacy, dosages, development of new candidates and adverse events through available literature.
小分子抑制剂靶向 JAKs（JAK 抑制剂）可以通过 JAK-STAT 通路调节细胞因子介导的信号转导，该通路在免疫调节和细胞增殖中发挥重要作用。JAK 抑制剂以前是为治疗涉及血液系统和免疫系统的疾病而设计和合成的。越来越多的证据表明，它们在特应性皮炎 (AD)、斑秃 (AA)、银屑病、白癜风等自身免疫性皮肤病中非常有效。目前，许多具有抗白癜风活性的 JAK 抑制剂正在实验室和临床中进行研究。有鉴于此，我们希望通过现有文献总结这些抑制剂的应用，重点介绍白癜风的特征、临床疗效、剂量、新候选药物的开发和不良反应。
