Yang Chieh-Hsin, Onda Danise-Ann, Oakhill Jonathan S, Scott John W, Galic Sandra, Loh Kim
St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.
Department of Medicine, University of Melbourne, Parkville, VIC 3010, Australia.
Endocrinology. 2021 Aug 1;162(8). doi: 10.1210/endocr/bqab070.
The neuropeptide Y (NPY) system has been recognized as one of the most critical molecules in the regulation of energy homeostasis and glucose metabolism. Abnormal levels of NPY have been shown to contribute to the development of metabolic disorders including obesity, cardiovascular diseases, and diabetes. NPY centrally promotes feeding and reduces energy expenditure, while the other family members, peptide YY (PYY) and pancreatic polypeptide (PP), mediate satiety. New evidence has uncovered additional functions for these peptides that go beyond energy expenditure and appetite regulation, indicating a more extensive function in controlling other physiological functions. In this review, we will discuss the role of the NPY system in the regulation of pancreatic β-cell function and its therapeutic implications for diabetes.
神经肽Y（NPY）系统已被公认为是能量稳态和葡萄糖代谢调节中最关键的分子之一。研究表明，NPY水平异常会导致包括肥胖、心血管疾病和糖尿病在内的代谢紊乱的发生。NPY在中枢促进进食并减少能量消耗，而其他家族成员，肽YY（PYY）和胰多肽（PP）则介导饱腹感。新证据揭示了这些肽除了能量消耗和食欲调节之外的其他功能，表明它们在控制其他生理功能方面具有更广泛的作用。在这篇综述中，我们将讨论NPY系统在胰腺β细胞功能调节中的作用及其对糖尿病的治疗意义。
