On a new class of mixed-function drugs associating nitroimidazoles and CENU: the NICE-NU.
作者信息
Carminati A, Barascut J L, Chenut E, Bourut C, Mathé G, Imbach J L
机构信息
Laboratoire de Chimie Bio-Organique, UA au CNRS, USTL, France, Montpellier.
出版信息
Anticancer Drug Des. 1988 Jun;3(1):57-65.
PMID:3382507
Abstract
Two series of (2-chloroethyl) nitrosoureas (NICE-NU) bearing a nitroimidazole group have been synthesized for anti-tumor evaluation with the aim of chemopotentiation of their biological activity. Their anti-tumor activity against L1210 in vivo in mice is excellent especially for the series A derivatives where a hydroxy function provides assistance to decomposition. However, the activity of NICE-NU against B16 melanoma is lower.
摘要
Zotero 插件