Schmied A, Amalric M, Dormont J F, Condé H, Farin D
Laboratoire de Neurobiologie et Neuropharmacologie du Développement, C.N.R.S. UA-1121, Université Paris-Sud, Orsay, France.
Behav Brain Res. 1988 Apr-May;28(1-2):207-16. doi: 10.1016/0166-4328(88)90098-8.
Cats were trained to release (Go) or not to release (No-go) a lever after a brief auditory signal, depending on the presence of an additional tone (No-go cue). Unit recording and cooling were made in the red nucleus (RN) contralateral to the performing limb. Three major results were found: (1) in the Go condition, we observed phasic increases of rubral firing, with a constant latency after the auditory signal and with an amplitude correlated to the latency of motor triggering (i.e. reaction time, RT); the tonic activity preceding the auditory signal could also be correlated to the RTs for some units; (2) in the No-go condition, there was no phasic increase of rubral firing after the auditory signal; the tonic activity during the presentation of the No-go cue was markedly decreased compared to the Go trials; (3) cooling of the RN increased the RTs and could also block the motor triggering. These results suggest that the RN is involved in setting and triggering a conditioned motor response according to sensory cues.
