奥氮平与喹硫平在预防产后女性双相情感障碍新发心境发作中的作用：一项回顾性队列研究。
Olanzapine and quetiapine in the prevention of a new mood episode in women with bipolar disorder during the postpartum period: a retrospective cohort study.
机构信息
Department of Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
出版信息
Braz J Psychiatry. 2021 Nov-Dec;43(6):617-620. doi: 10.1590/1516-4446-2020-1629.
OBJECTIVE
To examine whether olanzapine and quetiapine are useful in the prevention of a new mood episode during the postpartum period.
METHODS
Data on 23 patients (n=14 for olanzapine and n=9 for quetiapine) with bipolar disorder who met the criteria for this study were retrospectively gathered. The diagnosis of bipolar disorder was determined by means of the DSM-IV.
RESULTS
The mean follow-up period was 33.95±12.07 weeks. Six (26.1%) of 23 patients experienced recurrent mood episodes during the postpartum period. Four of these six patients were taking olanzapine and two were taking quetiapine. Patients with recurrent mood episodes had a significantly stronger family history of bipolar disorder, higher number of past episodes, and earlier onset and longer duration of illness compared to patients without recurrent mood episodes.
CONCLUSION
Monotherapy with olanzapine or quetiapine can be considered as an alternative to mood stabilizers in preventing the development of new mood episodes after childbirth.
目的
研究奥氮平与喹硫平是否有助于预防产后新发情绪发作。
方法
回顾性收集符合本研究标准的 23 例（奥氮平组 n=14，喹硫平组 n=9）双相障碍患者的数据。采用 DSM-IV 进行双相障碍的诊断。
结果
平均随访时间为 33.95±12.07 周。23 例患者中有 6 例（26.1%）在产后出现了复发性情绪发作。这 6 例患者中，4 例服用奥氮平，2 例服用喹硫平。与无复发性情绪发作的患者相比，有复发性情绪发作的患者有更强的双相障碍家族史、更多的既往发作次数、更早的发病时间和更长的病程。
结论
奥氮平或喹硫平单药治疗可作为产后预防新发情绪发作的心境稳定剂替代疗法。
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