Zhang Han, Wong Ting-Yat, Broekman Birit F P, Chong Yap-Seng, Shek Lynette P, Gluckman Peter D, Tan Kok Hian, Meaney Michael J, Fortier Marielle V, Qiu Anqi
School of Computer Engineering and Science, Shanghai University, Shanghai 200444, China.
Department of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.
Cereb Cortex. 2021 Jul 29;31(9):4233-4244. doi: 10.1093/cercor/bhab081.
Maternal childhood maltreatment and depression increase risks for the psychopathology of the offspring. This study employed a longitudinal dataset of mother-child dyads to investigate the developmental trajectories of brain functional networks and behaviors of children in relation with maternal childhood adverse experience and depression. Maternal childhood trauma was retrospectively assessed via childhood trauma questionnaire, whereas maternal depressive symptoms were prospectively evaluated during pregnancy and after delivery (n = 518). Child brain scans were acquired at age of 4.5, 6, and 7.5 years (n = 163) and behavioral problems were measured at 7.5 years using the Child Behavior Checklist. We found the functional connectivity of the language network with the sensorimotor, frontal, and attentional networks as a function of maternal adverse experience that interacted with sex and age. Girls exposed to mothers with depressive symptoms or childhood abuse showed the increased development of the functional connectivity of the language network with the visual networks, which was associated with social problems. Girls exposed to mothers with depressive symptoms showed the slower growth of the functional connectivity of the language network with the sensorimotor networks. Our findings, in a community sample, suggest the language network organization as neuroendophenotypes for maternal childhood trauma and depression.
母亲童年期受虐待和患抑郁症会增加后代精神病理学风险。本研究采用母子二元组纵向数据集，以调查儿童大脑功能网络的发育轨迹以及与母亲童年期不良经历和抑郁症相关的儿童行为。通过儿童创伤问卷对母亲童年期创伤进行回顾性评估，而在孕期和产后对母亲抑郁症状进行前瞻性评估（n = 518）。在儿童4.5岁、6岁和7.5岁时进行脑部扫描（n = 163），并在7.5岁时使用儿童行为量表测量行为问题。我们发现语言网络与感觉运动、额叶和注意力网络的功能连接是母亲不良经历的函数，且与性别和年龄存在交互作用。暴露于有抑郁症状或童年期受虐待母亲的女孩，其语言网络与视觉网络的功能连接发育增加，这与社交问题相关。暴露于有抑郁症状母亲的女孩，其语言网络与感觉运动网络的功能连接增长较慢。我们在社区样本中的研究结果表明，语言网络组织是母亲童年期创伤和抑郁症的神经内表型。
