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[1型糖尿病:最新进展]

[Type 1 diabetes: an update].

作者信息

Kordonouri Olga, Kerner Wolfgang

机构信息

Allgemeinpädiatrie, Diabetologie, Endokrinologie, Gastroenterologie und Klinische Forschung, Kinder- und Jugendkrankenhaus AUF DER BULT, Janusz-Korczak-Allee 12, 30173, Hannover, Deutschland.

Klinik für Diabetes und Stoffwechselerkrankungen, Klinikum Karlsburg, Karlsburg, Deutschland.

出版信息

Internist (Berl). 2021 Jun;62(6):627-637. doi: 10.1007/s00108-021-01009-w. Epub 2021 Apr 7.

Abstract

The incidence of type 1 diabetes (T1D) has been rising steadily over the last 30 years, especially among children and adolescents, with the result that the number of cases in this age group doubles every 20 years. The development of T1D goes through three stages, which can vary in duration from individual to individual. Late diagnosis or incorrect interpretation of the symptoms leads to the life-threatening diabetic ketoacidosis, from which every third child in Germany suffers at the manifestation of T1D. Diabetes that manifests in adulthood is regularly misclassified and treated, at least initially, as type 2 diabetes. There are no fundamental differences in the insulin therapy of T1D in children, adolescents and adults. The use of insulin pump therapy and continuous glucose monitoring is steadily increasing with the aim of reducing the number and duration of hypo- and hyperglycemic episodes, increasing the time in range between 70-180 mg/dl (3,9-10 mmol/l) and reaching the treatment goal of an HbA1c below 7% (53 mmol/mol). In addition to the prevention of diabetes-related long-term microvascular complications, the timely detection and treatment of cardiovascular risk factors is of extraordinary importance also for young people with T1D.

摘要

在过去30年中,1型糖尿病(T1D)的发病率一直在稳步上升,尤其是在儿童和青少年中,这使得该年龄组的病例数每20年就会翻一番。T1D的发展经历三个阶段,每个阶段的持续时间因人而异。诊断延迟或对症状的错误解读会导致危及生命的糖尿病酮症酸中毒,在德国,每三个患T1D的儿童在疾病发作时都会遭受这种情况。成年期出现的糖尿病通常会被错误分类并至少在初期被当作2型糖尿病进行治疗。儿童、青少年和成人T1D的胰岛素治疗没有根本区别。胰岛素泵治疗和持续血糖监测的使用正在稳步增加,目的是减少低血糖和高血糖发作的次数及持续时间,增加血糖在70-180mg/dl(3.9-10mmol/l)之间的时间,并达到糖化血红蛋白(HbA1c)低于7%(53mmol/mol)的治疗目标。除了预防与糖尿病相关的长期微血管并发症外,及时发现和治疗心血管危险因素对患有T1D的年轻人也极为重要。

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