TREM2 rs75932628 变异与肌萎缩侧索硬化症之间缺乏关联。
Lack of association between TREM2 rs75932628 variant and amyotrophic lateral sclerosis.
机构信息
Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, Larissa, Greece.
Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Mezourlo Hill, 41100, Larissa, Greece.
出版信息
Mol Biol Rep. 2021 Mar;48(3):2601-2610. doi: 10.1007/s11033-021-06312-1. Epub 2021 Apr 7.
Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease. Inflammatory processes are among the mechanisms that are implicated in ALS pathogenesis. The TREM2 rs75932628 T variant may influence the regulatory effect of TREM2 on inflammation. Studies regarding the role of the rs75932628 variant in ALS have yielded inconsistent results, so far. To assess the role of TREM2 rs75932628 on ALS risk. We genotyped 155 patients with sporadic ALS and 155 healthy controls for TREM2 rs75932628. We also merged and meta-analyzed our data with data from previous studies (with a total of 7524 ALS cases and 14,675 controls), regarding TREM2 rs75932628 and ALS. No ALS or healthy subjects carried the TREM2 rs75932628-T variant. Results from meta-analyses (overall approach and sensitivity analyses) yielded no significant results for possible connection between TREM2 rs75932628-T variant and ALS. Based on our results, TREM2 rs75932628 does not seem to play a determining role to the pathophysiology of ALS.
肌萎缩侧索硬化症（ALS）是一种多因素神经退行性疾病。炎症过程是ALS 发病机制中涉及的机制之一。TREM2 rs75932628 T 变体可能影响 TREM2 对炎症的调节作用。迄今为止，关于 rs75932628 变体在 ALS 中的作用的研究结果不一致。为了评估 TREM2 rs75932628 对 ALS 风险的作用。我们对 155 例散发性 ALS 患者和 155 名健康对照者进行了 TREM2 rs75932628 基因分型。我们还合并并荟萃分析了我们的数据和之前的研究数据（共 7524 例 ALS 病例和 14675 例对照），关于 TREM2 rs75932628 和 ALS。没有 ALS 或健康受试者携带 TREM2 rs75932628-T 变体。荟萃分析（整体方法和敏感性分析）的结果表明，TREM2 rs75932628-T 变体与 ALS 之间可能没有联系。基于我们的结果，TREM2 rs75932628 似乎在 ALS 的病理生理学中不起决定性作用。
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