通过输卵管内配子移植（GIFT）治疗正常精子型不孕症。

The treatment of normospermic infertility by gamete intrafallopian transfer (GIFT).

作者信息

Yovich J L, Matson P L, Blackledge D G, Turner S R, Richardson P A, Yovich J M, Edirisinghe W R

机构信息

PIVET Medical Centre, Leederville, Perth, Western Australia.

出版信息

Br J Obstet Gynaecol. 1988 Apr;95(4):361-6. doi: 10.1111/j.1471-0528.1988.tb06606.x.

DOI:10.1111/j.1471-0528.1988.tb06606.x

PMID:3382609

Abstract

Gamete intrafallopian transfer (GIFT) was applied in 207 treatment cycles in 73 couples. The pregnancy rate in cycles with only one (2/21, 9.5%) or two (2/29, 6.9%) oocytes transferred was significantly less than that in which four oocytes (36/116, 31.0%) were replaced. The collection of more than four oocytes did not influence the pregnancy rate in that treatment cycle. The overall pregnancy rate was 24.2% (50 of 207) and was similar in the four infertility groups studied (non-occlusive tubal disorders, endometriosis, cervical factor and unexplained infertility) with 28 (56%) of the pregnancies delivered at greater than or equal to 20 weeks. The pregnancy wastage included 4 (8%) ectopic pregnancies and 3 (6%) late pregnancy losses. The 12 multiple pregnancies occurred following the transfer of three and four oocytes.

摘要

配子输卵管内移植（GIFT）应用于73对夫妇的207个治疗周期。移植1个（2/21，9.5%）或2个（2/29，6.9%）卵母细胞的周期妊娠率显著低于移植4个卵母细胞（36/116，31.0%）的周期。采集超过4个卵母细胞对该治疗周期的妊娠率没有影响。总体妊娠率为24.2%（207个周期中有50个妊娠），在所研究的4种不孕不育组（非阻塞性输卵管疾病、子宫内膜异位症、宫颈因素和不明原因不孕）中相似，其中28例（56%）妊娠在孕20周及以上分娩。妊娠丢失包括4例（8%）异位妊娠和3例（6%）晚期妊娠丢失。12例多胎妊娠发生在移植3个和4个卵母细胞之后。