From the Department of Nuclear Medicine, Gazi Yaşargil Training and Research Hospital, University of Health Sciences, Diyarbakir, Turkey.
Clin Nucl Med. 2021 Aug 1;46(8):683-685. doi: 10.1097/RLU.0000000000003637.
68Ga-fibroblast activation protein-specific inhibitor (FAPI)-04 PET/CT was performed in a 49-year-old woman diagnosed with breast cancer. In PET/CT imaging, intense 68Ga-FAPI uptake was observed in the primary tumor, axillary lymph nodes, and also in the thyroid gland, whereas pathological 18F-FDG uptake was not observed in the thyroid gland. On thyroid ultrasonography, parenchyma was heterogeneous, and an area of focal thyroiditis was observed in the superior part of the right lobe. Biochemical parameters were found to be consistent with thyroiditis. This case shows that FAPI uptake in the thyroid gland may be associated with thyroiditis and should be evaluated clinically.
68Ga-成纤维细胞激活蛋白特异性抑制剂（FAPI）-04 PET/CT 在一位被诊断患有乳腺癌的 49 岁女性中进行。在 PET/CT 成像中，原发性肿瘤、腋窝淋巴结以及甲状腺均观察到强烈的 68Ga-FAPI 摄取，而甲状腺未见病理性 18F-FDG 摄取。甲状腺超声显示，实质不均匀，右叶上极可见局灶性甲状腺炎区域。生化参数与甲状腺炎相符。本病例表明，甲状腺的 FAPI 摄取可能与甲状腺炎有关，应进行临床评估。
