Bogousslavsky J, Regli F, Assal G
Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Brain. 1988 Jun;111 ( Pt 3):631-41. doi: 10.1093/brain/111.3.631.
Four of 1,200 consecutive patients with their first stroke showed acute transcortical mixed aphasia (TMA) characterized by nonfluent speech with impaired naming, semantic paraphasias, echolalia, impaired comprehension, good repetition, reading, and writing on dictation. All 4 had left internal carotid artery (ICA) occlusion with ipsilateral anterior pial territory infarction (precentral-central sulcus artery territory) and watershed infarction between the middle and posterior cerebral artery territories, which spared and 'isolated' the perisylvian speech areas. Although rare, acute TMA is highly suggestive of infarction due to ICA occlusion, in that it is probably related to simultaneous embolism (anterior pial infarction) and haemodynamic insufficiency (posterior watershed infarction).
在1200例首次发生卒中的连续患者中，有4例表现为急性经皮质混合性失语（TMA），其特征为言语不流畅、命名障碍、语义性错语、模仿言语、理解受损、复述、阅读及听写书写能力良好。所有4例均有左侧颈内动脉（ICA）闭塞，并伴有同侧软脑膜前动脉供血区梗死（中央前回-中央沟动脉供血区）以及大脑中动脉和大脑后动脉供血区之间的分水岭梗死，而外侧裂周围语言区得以保留且“孤立”。尽管急性TMA罕见，但高度提示由ICA闭塞所致的梗死，因为它可能与同时发生的栓塞（软脑膜前动脉梗死）和血流动力学不足（后分水岭梗死）有关。
