Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, P.R. China.
Eur Rev Med Pharmacol Sci. 2021 Mar;25(6):2511-2516. doi: 10.26355/eurrev_202103_25414.
To investigate the application of computed tomography (CT) perfusion imaging in non-small cell lung cancer (NSCLC) and its correlation with angiogenesis and lymph node metastasis.
A total of 100 patients with NSCLC were selected as the study subjects. They were admitted to our hospital from January 2013 to January 2018. All patients were examined by CT perfusion imaging after admission. The differences and correlations of CT perfusion imaging parameters between patients with different angiogenesis and pathological conditions were analyzed.
There was no significant difference in CT perfusion imaging parameters between patients with different tissue types. Blood flow (BF) in patients with lymph node metastasis was significantly higher than that in patients with non-lymph node metastasis. Blood value (BV) and peak enhancement index (PEI) in patients with lymph node metastasis were lower than those in patients with non-lymph node metastasis. There was no significant difference in mean transit time (MTT) between patients with different lymph node metastasis. The BF of stage I-II patients was significantly higher than that of stage III-IV patients, and there was no significant difference in other indexes (p < 0.05). There was significant difference in micro-vessel density (MVD) between patients with different pathological tissues and lymphatic metastasis (p < 0.05). There was no significant difference in MVD between patients with different TNM stages (p > 0.05). Lymph node metastasis and MVD are negatively correlated with CT perfusion imaging indices BF, BV and PEI, respectively.
CT perfusion imaging technology can reflect the formation of pulmonary capillaries and the ability of metastasis and dissemination of tumors to a certain extent.
探讨 CT 灌注成像在非小细胞肺癌（NSCLC）中的应用及其与血管生成和淋巴结转移的相关性。
选取 2013 年 1 月至 2018 年 1 月我院收治的 NSCLC 患者 100 例为研究对象，所有患者入院后均行 CT 灌注成像检查，分析不同血管生成及病理状况患者 CT 灌注成像参数的差异及相关性。
不同组织类型患者 CT 灌注成像参数比较，差异无统计学意义（P>0.05）；有淋巴结转移患者的血流（BF）明显高于无淋巴结转移患者，BV、PEI 明显低于无淋巴结转移患者，MTT 比较，差异无统计学意义（P>0.05）；Ⅰ-Ⅱ期患者 BF 明显高于Ⅲ-Ⅳ期患者，其他指标比较，差异无统计学意义（P>0.05）；不同病理组织及有无淋巴结转移患者 MVD 比较，差异有统计学意义（P<0.05）；不同 TNM 分期患者 MVD 比较，差异无统计学意义（P>0.05）；淋巴结转移与 MVD 与 CT 灌注成像指标 BF、BV、PEI 呈负相关。
CT 灌注成像技术能够在一定程度上反映肺部毛细血管的形成和肿瘤转移、扩散的能力。
