Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Alzheimers Dement. 2021 Oct;17(10):1641-1648. doi: 10.1002/alz.12331. Epub 2021 Apr 8.
Primary progressive aphasia (PPA) is a clinical dementia syndrome associated with frontotemporal lobar degeneration (FTLD) or Alzheimer's disease (AD). Impairment in activities of daily living is essential for dementia diagnosis, yet less is known about the neuropathologic impact on functional decline in PPA, especially over time.
Activities of Daily Living Questionnaire (ADLQ) ratings were compared by suspected underlying pathology between 17 PPA and 11 PPA participants at 6-month intervals for 2 years using a linear mixed-effects model. A general linear model examined associations between functional decline and cortical thickness at baseline.
Groups did not differ in demographics or aphasia severity at baseline, yet overall and subdomain scores of the ADLQ were significantly worse for PPA compared to PPA (P = .015) at each interval across 18 months.
Functional decline appears more pronounced and disrupts more aspects of life activities for individuals with non-semantic PPA with suspected AD versus non-AD neuropathology.
原发性进行性失语症（PPA）是一种与额颞叶变性（FTLD）或阿尔茨海默病（AD）相关的痴呆综合征。日常生活活动能力的损害是痴呆诊断的必要条件，但对于 PPA 中功能下降的神经病理学影响，尤其是随时间推移的影响，了解较少。
使用线性混合效应模型，对 17 名 PPA 和 11 名 PPA 参与者在 2 年内每 6 个月进行一次活动日常生活能力问卷（ADLQ）评分，按疑似潜在病理进行比较。一般线性模型检查了基线时功能下降与皮质厚度之间的关联。
两组在人口统计学或失语严重程度方面在基线时无差异，但在 18 个月的每个时间点，ADLQ 的总体和子域评分在 PPA 中明显差于 PPA（P=.015）。
与疑似非 AD 神经病理学的非语义性 PPA 个体相比，功能下降似乎更为明显，且更破坏了日常生活活动的多个方面。
