Folz R J, Gordon J I
Department of Biological Chemistry, Washington University School of Medicine, St Louis, MO 63110.
Comput Appl Biosci. 1988 Mar;4(1):175-9. doi: 10.1093/bioinformatics/4.1.175.
A new algorithm is presented which can be used to examine the physical-chemical properties of amino acids at sites of co- or post-translational processing. This algorithm has been incorporated into a computer program known as PARA-SITE. Thirty different parameters can be studied for amino acids which occupy comparable positions in naturally occurring proteins. PARA-SITE should aid in the design and interpretation of protein engineering experiments which seek to dissect structure/activity relationships.
提出了一种新算法，可用于检测共翻译或翻译后加工位点处氨基酸的物理化学性质。该算法已被纳入一个名为PARA-SITE的计算机程序中。对于在天然存在的蛋白质中占据可比位置的氨基酸，可以研究30种不同的参数。PARA-SITE应有助于设计和解释旨在剖析结构/活性关系的蛋白质工程实验。
