Department of Emergency Medicine, Bahat Hospital, Istanbul, Turkey.
Department of Emergency Medicine, Cerrahpasa Medical Faculty, Istanbul University - Cerrahpasa, Turkey.
J Laryngol Otol. 2021 Apr;135(4):336-340. doi: 10.1017/S0022215121000955. Epub 2021 Apr 8.
To investigate the usefulness of copeptin and S100B levels in the differentiation of central and peripheral vertigo.
Ninety patients were included in the study. Copeptin and S100B levels were measured using the enzyme-linked immunosorbent assay method.
The time between symptom onset and presentation to the emergency department was longer in the patients diagnosed with central vertigo. S100B and copeptin levels were significantly higher in central vertigo patients. The confirmed cut-off value was 17 for the S100B level and 1.65 for the copeptin level.
Quick and reliable differentiation between central and peripheral vertigo is important to reduce the length of hospital stay of patients in the emergency department, and for patient comfort. S100B and copeptin levels are potential biomarkers in the differential diagnosis of central vertigo and peripheral vertigo for patients whose aetiology of vertigo cannot be differentially diagnosed with history-taking and physical examination.
探讨 copeptin 和 S100B 水平在中枢性和周围性眩晕鉴别诊断中的作用。
纳入 90 例患者。采用酶联免疫吸附试验法测定 copeptin 和 S100B 水平。
中枢性眩晕患者的症状出现至就诊于急诊的时间较长。中枢性眩晕患者的 S100B 和 copeptin 水平显著升高。确定 S100B 水平的确诊截断值为 17，copeptin 水平的确诊截断值为 1.65。
快速可靠地区分中枢性和周围性眩晕对于减少急诊患者的住院时间、提高患者舒适度非常重要。S100B 和 copeptin 水平是病史和体格检查无法鉴别诊断眩晕病因的患者中枢性眩晕和周围性眩晕鉴别诊断的潜在生物标志物。
