Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
JCI Insight. 2021 Apr 8;6(7):147190. doi: 10.1172/jci.insight.147190.
Oxygen-sensing mechanisms allow cells to adapt and respond to changes in cellular oxygen tension, including hypoxic conditions. Hypoxia-inducible factor (HIF) is a central mediator in this fundamental adaptive response, and has critical functions in normal and disease physiology. Viruses have been shown to manipulate HIFs during their life cycle to facilitate replication and invasion. Conversely, HIFs are also implicated in the development of the host immune system and response to viral infections. Here, we highlight the recent revelations of host-pathogen interactions that involve the hypoxic response pathway and the role of HIF in emerging viral infectious diseases, as well as discussing potential antiviral therapeutic strategies targeting the HIF signaling axis.
氧感应机制使细胞能够适应和响应细胞氧张力的变化，包括缺氧条件。缺氧诱导因子 (HIF) 是这种基本适应反应的核心介质，在正常和疾病生理中具有关键功能。已经表明病毒在其生命周期中操纵 HIF 以促进复制和入侵。相反，HIF 也与宿主免疫系统的发育和对病毒感染的反应有关。在这里，我们强调了涉及低氧反应途径和 HIF 在新兴病毒感染性疾病中的作用的宿主-病原体相互作用的最新发现，并讨论了针对 HIF 信号轴的潜在抗病毒治疗策略。
