地塞米松调控免疫 62 年后迎击 COVID-19。
After 62 years of regulating immunity, dexamethasone meets COVID-19.
机构信息
Department of Medicine, Duke Human Vaccine Institute, Duke University, Durham, NC, USA.
The Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
出版信息
Nat Rev Immunol. 2020 Oct;20(10):587-588. doi: 10.1038/s41577-020-00421-x.
Abstract
Six months into the COVID-19 pandemic, effective treatments have been frustratingly sparse. The RECOVERY clinical trial, however, revealed that treatment with dexamethasone, a classic synthetic glucocorticoid, enhanced survival of critically ill patients with COVID-19. In this Comment, we discuss the immunological impacts of glucocorticoid therapy for COVID-19.
摘要
在 COVID-19 大流行的六个月中，有效的治疗方法一直令人沮丧地稀缺。然而，RECOVERY 临床试验表明，使用地塞米松（一种经典的合成糖皮质激素）治疗 COVID-19 重症患者可提高其生存率。在本评论中，我们讨论了糖皮质激素治疗 COVID-19 的免疫学影响。
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