Dr Anju Choudhary, Senior Resident, Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan, India; E-mail:
Mymensingh Med J. 2021 Apr;30(2):531-537.
Infertility is a growing health problem. It affects relatively large number of couples both globally as well as in India. Fertility treatment registers suggest that infertility is on increase. With the advancement in the knowledge and technology about the In Vitro fertilization (IVF) process, In Vitro fertilization success rates are improving over the time. In many cases of male-factor infertility, Intracytoplasmic sperm injection (ICSI) is the recommended treatment. The aim of this study was to estimate fertilization, implantation and pregnancy rates in ICSI cycles in association with number of attempts and sperm morphology. A total of 250 IVF-ICSI cycles were performed at a Fertility Center in Jaipur, Rajasthan, India. This cohort study was performed during 2013 to 2015. The differences in the outcomes of ICSI in association with sperm morphology and number of ICSI attempt were evaluated. Significantly higher mean was observed in fertilization rate and live birth rate with ≥5% sperm morphology 79.63% vs. 71.46% and 20% vs. 13.9% respectively). Significantly higher mean implantation rate and clinical pregnancy rate (CPR) and live birth rate were observed with attempt 3 as compared to 1 and 2 attempts. IVF success rates are improving over the time as knowledge and technology are advancing. Sperm morphology and number of attempt affect the ICSI outcomes.
不孕是一个日益严重的健康问题。它在全球和印度都影响着相当数量的夫妇。生育治疗登记册表明，不孕不育的发病率正在上升。随着人们对体外受精（IVF）过程的认识和技术的进步，体外受精的成功率也在不断提高。在许多男性因素导致的不孕不育病例中，胞浆内单精子注射（ICSI）是推荐的治疗方法。本研究旨在评估与尝试次数和精子形态相关的 ICSI 周期中的受精、着床和妊娠率。在印度拉贾斯坦邦斋浦尔的一个生育中心进行了 250 个 IVF-ICSI 周期。这项队列研究是在 2013 年至 2015 年进行的。评估了与精子形态和 ICSI 尝试次数相关的 ICSI 结果的差异。具有≥5%精子形态的患者的受精率和活产率明显较高，分别为 79.63%比 71.46%和 20%比 13.9%。与 1 次和 2 次尝试相比，尝试 3 次的患者的着床率、临床妊娠率（CPR）和活产率明显较高。随着知识和技术的进步，体外受精的成功率也在不断提高。精子形态和尝试次数会影响 ICSI 的结果。
