School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
Key Laboratory of Advanced Technology for Materials of the Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
Mol Cell Biochem. 2021 Aug;476(8):3089-3097. doi: 10.1007/s11010-021-04145-x. Epub 2021 Apr 8.
The hydrogen-rich water (HW) has been reported to possess a beneficial role in patients with diabetes. However, a systemic evaluation with an appropriate animal model is necessary to reveal its mechanisms and efficacy. Herein, the protective effects of drinking HW on lipid and glucose metabolism, oxidative stress, and inflammation in type 2 diabetes mellitus (T2DM) rats were investigated. The well-modeled T2DM rats (induced by high-fat diet combined with low-dose streptozotocin (STZ) injection) were divided into two groups (n ≥ 15 of each): fed a high-fat diet and drinking distilled water or HW at a constant concentration above 1.0 ppm; normal rats were used as control group (n ≥ 10): fed a regular diet and drinking distilled water. Several biomarkers of lipid and glucose metabolism, oxidative stress ,and inflammation were evaluated after drinking distilled water or HW for 3 weeks. The effect of HW on liver, kidney, and spleen of T2DM rats was also analyzed by HE and Oil Red O staining. The results showed that drinking HW suppressed the increase in glucose, total cholesterol, oxidative stress, and inflammation. Moreover, HW also ameliorates hyperglycemia-induced liver, kidney, and spleen dysfunction. Overall, this study indicates that patients with T2DM may be able to improve their condition by supplementing HW as daily drinking water.
富氢水（HW）已被报道在糖尿病患者中具有有益作用。然而，需要使用适当的动物模型进行系统评价，以揭示其机制和疗效。在此，研究了饮用 HW 对 2 型糖尿病（T2DM）大鼠脂质和葡萄糖代谢、氧化应激和炎症的保护作用。通过高脂肪饮食联合小剂量链脲佐菌素（STZ）注射成功建模的 T2DM 大鼠（n≥15 只/组）分为两组：饮用高脂肪饮食并持续饮用浓度高于 1.0ppm 的蒸馏水或 HW；正常大鼠作为对照组（n≥10 只）：饮用常规饮食并饮用蒸馏水。在饮用蒸馏水或 HW 3 周后，评估了脂质和葡萄糖代谢、氧化应激和炎症的几个生物标志物。还通过 HE 和油红 O 染色分析了 HW 对 T2DM 大鼠肝、肾和脾的影响。结果表明，饮用 HW 抑制了血糖、总胆固醇、氧化应激和炎症的增加。此外，HW 还改善了高血糖引起的肝、肾和脾功能障碍。总的来说，这项研究表明，T2DM 患者可能能够通过补充 HW 作为日常饮用水来改善病情。
