Quintáns J
Eur J Immunol. 1977 Oct;7(10):749-51. doi: 10.1002/eji.1830071020.
The in vivo responses of CBA/N (which have an X-linked defect of B lymphocyte differentiation) and CBA/J normal mice to 2,4,6-trinitrophenylated (TNP) bacteriophage T4 and Diplococcus pneumoniae CS variant have been compared. Both antigens are thymus-independent (TI), and TNP-CS additionally contains the phosphorylcholine (PC) epitope, CBA/N and CBA/J mice give TNP plaque-forming cell responses similar in magnitude and avidity although only CBA/J give a PC response when challenged with TNP-CS. These results indicate that CBA/N mice have a "patchy" defect of antigen-induced humoral responses. This defect is manifested only in certain subpopulations of B cells and is not restricted to TI responses.
已比较了CBA/N（具有X连锁的B淋巴细胞分化缺陷）和CBA/J正常小鼠对2,4,6-三硝基苯化（TNP）噬菌体T4和肺炎双球菌CS变体的体内反应。两种抗原均为非胸腺依赖性（TI），并且TNP-CS还含有磷酰胆碱（PC）表位，CBA/N和CBA/J小鼠产生的TNP斑块形成细胞反应在强度和亲和力上相似，尽管在用TNP-CS攻击时只有CBA/J产生PC反应。这些结果表明，CBA/N小鼠存在抗原诱导的体液反应的“斑驳”缺陷。这种缺陷仅在某些B细胞亚群中表现出来，并且不限于TI反应。
