Department of Surgical Oncology, City of Hope National Medical Center, Duarte, California, USA.
Department of Radiation Oncology, City of Hope National Medical Center, Duarte, California, USA.
J Surg Oncol. 2021 May;123(6):1395-1404. doi: 10.1002/jso.26415.
The annual incidence of pancreatic cancer is nearly 50,000 patients. The 5-year overall survival is only 9%, and there remains a great need for better therapy. A subset of these patients presents with locally advanced disease. Multidisciplinary therapy has evolved to include some combination of systemic chemotherapy, locoregional radiation, and surgery in select patients with excellent biology. This review will address the thoughtful evidence-based and individualized approach to these patients.
每年胰腺癌的发病率接近 5 万例。患者的 5 年总生存率仅为 9%，因此仍然迫切需要更好的治疗方法。这些患者中有一部分表现为局部晚期疾病。多学科治疗已经发展到包括某些组合的全身化疗、局部区域放疗以及在生物学表现良好的患者中进行的手术。这篇综述将讨论对这些患者进行的基于深思熟虑的循证和个体化方法。
