PD-1 和 PD-L1 在复发性自然流产患者中的表达及意义：系统评价和荟萃分析方案。

Expression and significance of PD-1 and PD-L1 in patients with recurrent spontaneous abortion: A protocol for systematic review and meta-analysis.

机构信息

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education.

Department of Obstetrics and Gynecology.

出版信息

Medicine (Baltimore). 2021 Apr 9;100(14):e25444. doi: 10.1097/MD.0000000000025444.

DOI:10.1097/MD.0000000000025444

PMID:33832149

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8036024/

Abstract

BACKGROUND

Recurrent spontaneous abortion (RSA) accounts for the most common complication of early pregnancy in humans. As an immune checkpoint pathway, programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) can be exploited by tumor cells to evade immuno-surveillance. Many studies have shown that the expression of PD-1/PD-L1 is involved in RSA. However, the correlation between the expression of PD-1/PD-L1 and RSA is still controversial. We conducted meta-analysis to further explore the correlation between the expression of PD-1/PD-L1 and RSA, to provide a basis for clinical prevention and treatment.

METHODS

We will search PubMed, Embase, Web of Science, Google Scholar, Chinese National Knowledge Infrastructure, Chinese VIP Information, Wanfang Database, and Chinese Biomedical Literature Database for related published studies before February 2021. Two review authors will search and assess relevant studies independently. Case control studies and cohort studies will be included. The Revman 5.3 software was applied to carry out the meta-analysis for the included literature.

RESULTS

The findings of this systematic review will be disseminated in a peer-reviewed publication and/or presented at relevant conferences.

CONCLUSION

This study will provide a new theoretical basis for the prevention and treatment of RSA.

TRIAL REGISTRATION NUMBER

DOI 10.17605/OSF.IO/CZD23.Ethics and dissemination: Formal ethical approval is not required, as the data are not individualized.

摘要

背景

复发性自然流产（RSA）是人类早期妊娠最常见的并发症。作为免疫检查点途径，程序性死亡-1（PD-1）和程序性死亡配体-1（PD-L1）可被肿瘤细胞利用来逃避免疫监视。许多研究表明，PD-1/PD-L1 的表达与 RSA 有关。然而，PD-1/PD-L1 的表达与 RSA 之间的相关性仍存在争议。我们进行了荟萃分析，以进一步探讨 PD-1/PD-L1 的表达与 RSA 之间的相关性，为临床预防和治疗提供依据。

方法

我们将在 2021 年 2 月之前检索 PubMed、Embase、Web of Science、Google Scholar、中国国家知识基础设施、中国 VIP 信息、万方数据库和中国生物医学文献数据库中相关的已发表研究。两名综述作者将独立搜索和评估相关研究。纳入病例对照研究和队列研究。采用 Revman 5.3 软件对纳入文献进行荟萃分析。