抗磷脂抗体与狼疮肾炎患者临床活动和肾脏病理活动的相关性。

Association of antiphospholipid antibodies with clinical activity and renal pathological activity in patients with lupus nephritis.

机构信息

Department of Nephrology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Department of Nephrology, First Affiliated Hospital of Soochow University, Suzhou, China.

出版信息

Lupus. 2021 Jun;30(7):1140-1145. doi: 10.1177/09612033211006781. Epub 2021 Apr 8.

DOI:10.1177/09612033211006781

PMID:33832360

Abstract

OBJECTIVES

This study aimed to investigate the association of antiphospholipid antibodies (aPL) with clinical activity and renal pathological activity in patients with lupus nephritis (LN).

METHODS

Levels of anticardiolipin () antibodies, anti-β2-glycoprotein I (anti-β2-GPI) antibodies and lupus anticoagulant (LAC) were measured, and other clinical and pathological data were also obtained during the same period before renal biopsy.

RESULTS

A total of 83 patients with LN were included in this study, 40 patients (48.2%) in the s positive group and 43 patients in the aPL negative group. LN patients with positive aPL had significantly higher SLEDAI (p = 0.012), more hematuria (p = 0.043), lower serum C3 (p = 0.003) and C4 (p = 0.014), and a higher pathological activity index (p = 0.012), more micro-thrombosis (p = 0.046) and more C3 deposits (p = 0.038) in the glomerulus than patients with negative aPL The level of IgG- was significantly correlated with SLEDAI and serum level of C3 (r = 0.44, p < 0.001; r = -0.39, p = 0.003, respectively). The level of IgM- was significantly correlated with SLEDAI, and serum levels of C3 and C4 (r = 0.27, p = 0.014; r = -0.22, p = 0.041; r = -0.23, p = 0.035, respectively).

CONCLUSIONS

Our work suggests that aPL, especially, are correlated with both clinical activity and renal pathological activity in patients with LN.

摘要

目的

本研究旨在探讨抗磷脂抗体（aPL）与狼疮肾炎（LN）患者临床活动和肾脏病理活动的相关性。

方法

在肾活检同期检测抗心磷脂抗体（）、抗β2-糖蛋白 I（抗β2-GPI）抗体和狼疮抗凝物（LAC）水平，并获取其他临床和病理资料。

结果

本研究共纳入 83 例 LN 患者，其中 aPL 阳性组 40 例（48.2%），aPL 阴性组 43 例。aPL 阳性的 LN 患者 SLEDAI 评分更高（p = 0.012），血尿更多（p = 0.043），血清 C3（p = 0.003）和 C4 水平更低（p = 0.014），病理活动指数更高（p = 0.012），肾小球内微血栓形成更多（p = 0.046）和 C3 沉积更多（p = 0.038）。IgG-水平与 SLEDAI 及血清 C3 水平呈显著正相关（r = 0.44，p < 0.001；r = -0.39，p = 0.003）。IgM-水平与 SLEDAI 及血清 C3 和 C4 水平呈显著负相关（r = 0.27，p = 0.014；r = -0.22，p = 0.041；r = -0.23，p = 0.035）。