Institute of Experimental Medicine, 197376 Saint-Petersburg, Russia.
Biochemistry (Mosc). 2021 Feb;86(2):146-155. doi: 10.1134/S0006297921020036.
L-arginine is a key metabolite for nitric oxide production by endothelial cells, as well as signaling molecule of the mTOR signaling pathway. mTOR supports endothelial cells homeostasis and regulates activity of L-arginine-metabolizing enzymes, endothelial nitric oxide synthase, and arginase II. Disruption of the L-arginine metabolism in endothelial cells leads to the development of endothelial dysfunction. Conflicting results of the use of L-arginine supplement to improve endothelial function reveals a controversial role of the amino acid in the endothelial cell biology. The review is aimed at analysis of the current data on the role of L-arginine metabolism in the development of endothelial dysfunction.
精氨酸是内皮细胞一氧化氮生成的关键代谢物，也是 mTOR 信号通路的信号分子。mTOR 支持内皮细胞的稳态，并调节精氨酸代谢酶、内皮型一氧化氮合酶和精氨酸酶 II 的活性。内皮细胞中精氨酸代谢的破坏导致内皮功能障碍的发展。补充精氨酸以改善内皮功能的结果相互矛盾，这表明该氨基酸在内皮细胞生物学中具有争议性的作用。本文旨在分析精氨酸代谢在内皮功能障碍发展中的作用的现有数据。
