Department of Internal Medicine, Wayne State University, 4201 St Antoine, UHC 5C, Detroit, MI, 48201, USA.
Wayne State University, Detroit, MI, USA.
Respir Res. 2021 Apr 9;22(1):102. doi: 10.1186/s12931-021-01703-1.
We would like to comment on the recently published article titled: "Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients" by Ricci et al. The authors grouped the patients into two groups according to the vitamin D levels measured at the time of admission into the hospital and reported that lower vitamin D levels are associated with elevated D-dimer and IL-6 levels, low CD4/CD8 ratio and compromised clinical findings with elevated LIPI and SOFA scores. However, review of recent literature shows this association to be debatable. The 25-hydroxyvitamin D levels in the initial phase of critical illness have been reported to drop rapidly and hence consideration of the time of measurement from symptom onset would have enhanced the clinical relevance of these findings. Inferred association between vitamin D levels and disease severity based on SOFA score in COVID-19 patients, needs to be further explored in the light of the recent literature which casts doubt on using SOFA score at admission to predict mortality in COVID-19.
我们想对 Ricci 等人最近发表的题为“COVID-19 患者循环维生素 D 水平状况和临床预后指标”的文章进行评论。作者根据入院时测量的维生素 D 水平将患者分为两组，并报告说较低的维生素 D 水平与升高的 D-二聚体和 IL-6 水平、较低的 CD4/CD8 比值以及升高的 LIPI 和 SOFA 评分有关的临床发现受损有关。然而，对最近文献的回顾表明，这种关联是有争议的。在危重病的初始阶段，25-羟维生素 D 水平已被报道迅速下降，因此从症状出现开始考虑测量时间将增强这些发现的临床相关性。基于 COVID-19 患者 SOFA 评分推断的维生素 D 水平与疾病严重程度之间的关联，需要根据最近的文献进一步探讨，这些文献对使用入院时的 SOFA 评分来预测 COVID-19 患者的死亡率提出了质疑。
