Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia; Department of Medicine - Western Health, The University of Melbourne, Melbourne, VIC, Australia; The Australian Institute for Musculoskeletal Science, The University of Melbourne, Victoria University and Western Health, Melbourne, VIC, Australia.
Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia; The Australian Institute for Musculoskeletal Science, The University of Melbourne, Victoria University and Western Health, Melbourne, VIC, Australia.
Maturitas. 2021 May;147:7-13. doi: 10.1016/j.maturitas.2021.02.006. Epub 2021 Feb 26.
Cellular senescence is a critical part of human anti-tumor defence; however, the accumulation of senescent cells with age underpins a wide range of pathologies. Senescent change in immune cells, or immunosenescence, has a wide range of physiological effects and is at least partially responsible for many diseases associated with aging. Immunosenescence underpins inflammaging, increased vulnerability to infectious disease with age, malignant change in the elderly, and auto-immunity. Understanding the effects and mechanisms of immunosenescence will improve disease outcomes and prevention in older adults, and generate new treatments for common illnesses. In this review we summarize the key changes occurring in immunosenescence across each facet of the immune system, and identify their clinical correlates.
细胞衰老（cellular senescence）是人体抗肿瘤防御的关键部分；然而，随着年龄的增长，衰老细胞的积累是多种病理学的基础。免疫细胞的衰老变化（senescent change in immune cells），即免疫衰老（immunosenescence），具有广泛的生理影响，至少部分导致与衰老相关的许多疾病。免疫衰老（immunosenescence）是炎症衰老（inflammaging）、随着年龄增长易感染性疾病（infectious disease）增加、老年人恶性变化（malignant change）和自身免疫（autoimmunity）的基础。了解免疫衰老的影响和机制将改善老年人的疾病结局和预防，并为常见疾病提供新的治疗方法。在这篇综述中，我们总结了免疫系统各个方面发生的关键变化，并确定了它们的临床相关性。
