Faculty of Pharmacy, Gomal University, D.I.Khan, KPK, Pakistan.
Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
Pak J Pharm Sci. 2020 Sep;33(5(Supplementary)):2231-2237.
Controlled release formulations are administered once a day and reduce frequency of dose and ensuring patient's compliance. In the current research controlled release matrices of losartan potassium formulated with polymeric combinations of ethocel grade 7 with carbopol 934P NF using different concentrations of polymers. In some polymeric tablets, Co-excipients like CMC, Starch, HPMC was added by replacing of 10% of filler in formulations at 10:5. Tablets were prepared by direct compression method and evaluated for physicochemical characteristics. USP Method-1 (rotating basket method) was used to carry out dissolution study in phosphate buffer pH 6.8. Drug release kinetics determined and comparison of dissolution patterns was done with reference tablets. The polymeric combinations well retarded drug release and drug was released by anamolous non-fickian diffusion mechanism. Dissolution profiles of tested tablets and reference tablets were found not similar. Drug release rate was increased by co-excipients. It was concluded from this research work that this polymeric combination can be used efficiently in designing of controlled release martices.
控释制剂每天给药一次，减少了给药次数，确保了患者的依从性。在目前的研究中，用不同浓度的聚合物将洛沙坦钾的控释基质与乙基纤维素等级 7 与卡波姆 934P NF 的聚合物组合配制成控释基质。在一些聚合物片剂中，通过用填充剂的 10%代替配方中的辅料（如 CMC、淀粉、HPMC）来添加共赋形剂。采用直接压片法制备片剂，并对其理化性质进行评价。采用 USP 方法-1（旋转篮法）在磷酸盐缓冲液 pH6.8 中进行溶出度研究。确定药物释放动力学，并与参比片剂比较溶出模式。聚合物组合能很好地延缓药物释放，药物通过非菲克扩散机制释放。测试片剂和参比片剂的溶出曲线并不相似。共赋形剂增加了药物释放速度。从这项研究工作可以得出结论，这种聚合物组合可以有效地用于设计控释基质。
