Department of Food Science, Faculty of Life Sciences, Govt. College University, Faisalabad, Pakistan.
Department of Food Science & Technology, MNSUA, Multan, Pakistan.
Pak J Pharm Sci. 2020 Sep;33(5(Supplementary)):2249-2255.
Stevia rebaudiana Bertoni a non-caloric, safe and natural sweetener has been shown pharmaceutically important in the management of blood disorders. This study was designed to investigate hematology and safety of stevia aqueous extract through animal modeling. For this purpose, fifty albino rats were categorized into 5 groups and all the groups were received aqueous stevia extract at different dosage levels (200, 300, 400 and 500 ppm/kg b. wt) for 8 weeks except control group. Hematological and toxicological analyses were conducted using standard recommended procedures. The results indicated that biochemical parameters (RBC, HB, HCT, MCV, MCH, MCHC, WBC, eosinophils, lymphocytes and neutrophils) of albino rats significantly (P<0.05) increased and PLT, MPV and monocytes levels non-significantly decreased by using aqueous extract of stevia at different levels after eight weeks of study. Furthermore, Stevia aqueous extracts had non-toxic effect on liver functioning tests. However, stevia aqueous extracts were insignificant in their impression regarding organ to body weight ratios. The stevia aqueous extract has positive effect on hematological parameters of albino rats and is toxicologically safe. Therefore it could be used as a natural remedy for the management of hematological disorders without any health hazards.
甜菊糖 Rebaudiana 是一种无热量、安全和天然的甜味剂，已被证明在治疗血液疾病方面具有重要的药用价值。本研究旨在通过动物模型研究甜菊叶水提物的血液学和安全性。为此，将 50 只白化大鼠分为 5 组，除对照组外，所有组均在 8 周内以不同剂量（200、300、400 和 500ppm/kg 体重）接受甜菊叶水提物。使用标准推荐的程序进行血液学和毒理学分析。结果表明，在研究 8 周后，甜菊叶水提物在不同水平上使用时，大鼠的生化参数（RBC、HB、HCT、MCV、MCH、MCHC、WBC、嗜酸性粒细胞、淋巴细胞和中性粒细胞）显著（P<0.05）增加，PLT、MPV 和单核细胞水平非显著降低。此外，甜菊叶水提物对肝功能试验无毒性作用。然而，甜菊叶水提物对器官与体重比的影响并不显著。甜菊叶水提物对大鼠的血液学参数有积极影响，且在毒理学上是安全的。因此，它可以作为一种天然药物，用于治疗血液疾病，而不会产生任何健康危害。
