耐甲氧西林定植与 40-85 岁社区成年人死亡率的相关性研究。
Methicillin-Resistant Colonization and Mortality Risk Among Community Adults Aged 40-85.
机构信息
From the Department of Health Services Research, Management and Policy, University of Florida (AGM); Department of Community Health and Family Medicine, University of Florida (AGM, BJR, PJC).
出版信息
J Am Board Fam Med. 2021 Mar-Apr;34(2):439-441. doi: 10.3122/jabfm.2021.02.200394.
INTRODUCTION
The objective of this study was to assess the 11-year mortality risk of methicillin-resistant (MRSA) colonization in community-dwelling adults aged 40 to 85 years.
METHODS
The study analyzed the National Health and Nutrition Examination Survey (NHANES) 2001 to 2004 linked to the National Death Index through December 31, 2015. Our cohort of community adults aged 40 to 85 years was 6085 participants (representing 118 718 486 adults). Mortality risk from MRSA colonization was examined with an 11-year follow-up.
RESULTS
The 11-year mortality rates were 35.9% (95% CI, 25.4%- 46.4%) for MRSA-colonized and 17.8% (95% CI, 16.4%- 19.2%) for non-colonized participants. After adjusting for potential confounders the hazard ratio for mortality among those colonized with MRSA was 1.75 (95% CI, 1.12-2.73).
DISCUSSION
MRSA colonization in middle-aged and older adults in the community is associated with a significantly increased mortality risk. Considering that this effect was in the community and not in hospitalized patients, this finding of increased mortality risk is especially troubling.
简介
本研究旨在评估 40 至 85 岁社区居住成年人耐甲氧西林金黄色葡萄球菌（MRSA）定植的 11 年死亡率风险。
方法
本研究分析了 2001 年至 2004 年全国健康和营养调查（NHANES）与 2015 年 12 月 31 日国家死亡指数的关联。我们的社区成年人队列年龄在 40 至 85 岁之间，有 6085 名参与者（代表 118718486 名成年人）。用 11 年的随访时间来检查 MRSA 定植的死亡率风险。
结果
MRSA 定植者的 11 年死亡率为 35.9%（95%置信区间，25.4%-46.4%），而非定植者的死亡率为 17.8%（95%置信区间，16.4%-19.2%）。在校正了潜在的混杂因素后，MRSA 定植者的死亡风险比为 1.75（95%置信区间，1.12-2.73）。
讨论
社区中年和老年人中 MRSA 定植与死亡率风险显著增加相关。考虑到这种影响发生在社区而不是住院患者中，这种死亡率风险增加的发现尤其令人不安。
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