Department of Neurology, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Blood Press Monit. 2021 Aug 1;26(4):288-291. doi: 10.1097/MBP.0000000000000538.
Our study aimed to evaluate the effect of fluoxetine on morning blood pressure surge (MBPS) in patients with ischemic stroke.
A total of 30 patients with acute ischemic stroke, 15 in the control group and 15 in the treatment group, were enrolled. Two patients in the control group and one in the treatment group were lost during follow-up. The patients in the treatment group were treated with fluoxetine (20 mg per day for 3 months) based on the treatments in the control group. Baseline characteristics, Patient Health Questionnaire 9 (PHQ-9) items scale score, mean blood pressure and MBPS were evaluated before and after treatment, and the correlation between the improvements of PHQ-9 scale score and MBPS was also analyzed.
The mean SBP and the systolic and diastolic MBPS in the treatment group were significantly lower than that in the control group after 3 months of treatment (P = 0.024, P = 0.022, P = 0.001, respectively). Besides, the improvement of PHQ-9 scale score was significantly higher in the treatment group than in the control group (P = 0.049). There was no significant correlation between the improvement of systolic or diastolic MBPS and the improvement of PHQ-9 scale score in the treatment group (P = 0.289 and P = 0.206, respectively).
Fluoxetine might improve MBPS in patients with ischemic stroke.
本研究旨在评估氟西汀对缺血性脑卒中患者晨血压骤升（MBPS）的影响。
共纳入 30 例急性缺血性脑卒中患者，其中对照组 15 例，治疗组 15 例。对照组有 2 例患者和治疗组有 1 例患者在随访过程中失访。治疗组在对照组治疗基础上加用氟西汀（20 mg/d，共 3 个月）。评估治疗前后两组患者的基线特征、患者健康问卷 9（PHQ-9）项量表评分、平均血压和 MBPS，分析 PHQ-9 项量表评分改善与 MBPS 之间的相关性。
治疗 3 个月后，治疗组的平均收缩压和收缩压及舒张压 MBPS 均显著低于对照组（P = 0.024、P = 0.022、P = 0.001）。此外，治疗组 PHQ-9 项量表评分的改善显著高于对照组（P = 0.049）。治疗组中，收缩压或舒张压 MBPS 的改善与 PHQ-9 项量表评分的改善之间无显著相关性（P = 0.289 和 P = 0.206）。
氟西汀可能改善缺血性脑卒中患者的 MBPS。
