Research Physician and Principal Investigator, Botswana Harvard HIV/AIDS Partnership.
Program Manager, Botswana Harvard HIV/AIDS Partnership.
Curr Opin HIV AIDS. 2021 May 1;16(3):163-167. doi: 10.1097/COH.0000000000000676.
The present review aims to decipher common co-morbidities faced by people living with HIV in low- to middle-income countries, and in particular the sub-Saharan region, which hosts the majority of the HIV burden worldwide.
Well-controlled chronic HIV disease is strongly associated with an increased risk of developing cardiovascular disease. This is partly due to the natural aging process, however recent studies show that using antiretroviral therapy as well as the HIV disease itself may be predisposing factors to the development of cardiovascular diseases, creating a new burden for healthcare facilities in the region. Furthermore, newly completed studies assessing inflammation marker albuminuria and age-related syndrome frailty have been found in a higher prevalence than in non-HIV people, with increased morbidity and mortality.
As antiretroviral medication continues to be well supplied in the region and well tolerated by patients living with HIV, this group is now reckoning with cardiovascular ailments faced by all ageing population therefore there is a need for cardiovascular care systems to be better integrated within the existing, well-performing HIV care cascade to address this burden.
本综述旨在解析中低收入国家(尤其是全球 HIV 负担主要集中的撒哈拉以南非洲地区)中 HIV 感染者常见的合并症。
慢性 HIV 疾病得到良好控制与发生心血管疾病的风险增加密切相关。这部分归因于自然衰老过程,但最近的研究表明,使用抗逆转录病毒疗法以及 HIV 疾病本身可能是导致心血管疾病发生的诱发因素,给该地区的医疗保健设施带来了新的负担。此外,新完成的研究评估了炎症标志物白蛋白尿和与年龄相关的综合征脆弱性,发现其在 HIV 感染者中的患病率高于非 HIV 感染者,发病率和死亡率更高。
随着抗逆转录病毒药物在该地区持续供应且 HIV 感染者患者耐受良好,这一群体现在正面临所有老年人群都面临的心血管疾病,因此需要更好地将心血管保健系统纳入现有的、运行良好的 HIV 保健护理体系,以应对这一负担。