Mazti Asmae, El Idrissi Mohamed, El Ibrahimi Abdelhalim, Maaroufi Mustapha El, El Koubaiti Ghizlane, Bouhafa Touria, El Fakir Samira, Arifi Samia, Mrini Abdelmajid, Chbani Laila
Department of Pathology, Hassan II University Hospital, Fez, Morocco.
Department of Radiology, Hassan II University Hospital, Fez, Morocco.
Int J Surg Oncol. 2021 Mar 24;2021:8871557. doi: 10.1155/2021/8871557. eCollection 2021.
Soft-tissue sarcomas are malignant tumors that require good management within specialized centers. Our study aims to assess the benefit of handling these kinds of tumors using the Multidisciplinary Meeting (MDM) approach. The current paper details this approach through a prospective study that has lasted for 42 months in the HASSAN II University Hospital Center, Fez, Morocco. During this research work, 116 cases were selected with an average age of 53 years. In 95.7% of the cases, it was found that the lower limb was the most frequent tumor type (78.4%). Also, ninety-two (92) patients (79.3%) have had a prior biopsy. Ninety-nine (99) patients (85.3%) have received a magnetic resonance imaging scan (MRI) before surgery. Sixty-three (63) patients were operated on, including R0 resection used for 37 patients, R1 used for 21 patients, and R2 used for five patients. As a result, liposarcomas were the most frequent type (30.1%), followed by synovial sarcomas (14.6%), leiomyosarcomas (9.5%), ewing sarcoma (8.6), and undifferentiated pleomorphic sarcomas (7.7%). In addition, neoadjuvant chemotherapy was used for 36 patients. The other 22 patients received adjuvant chemotherapy and/or radiotherapy. The overall survival rate was 60.56 months, which proves a significant improvement, thanks to the multidisciplinary meeting approach. . The conducted investigation has shown that using MDM for managing soft-tissue sarcomas of extremities improves the patients' survival rate. Moreover, results have proven MDM might allow optimal treatment regarding less local recurrence and metastasis.
软组织肉瘤是需要在专业中心进行妥善管理的恶性肿瘤。我们的研究旨在评估采用多学科会诊（MDM）方法处理这类肿瘤的益处。本文通过在摩洛哥非斯的哈桑二世大学医院中心进行的一项为期42个月的前瞻性研究，详细阐述了这种方法。在这项研究工作中，选取了116例病例，平均年龄为53岁。在95.7%的病例中，发现下肢是最常见的肿瘤部位（78.4%）。此外，92例（79.3%）患者曾接受过活检。99例（85.3%）患者在手术前接受了磁共振成像扫描（MRI）。63例患者接受了手术，其中37例采用R0切除，21例采用R1切除，5例采用R2切除。结果显示，脂肪肉瘤是最常见的类型（30.1%），其次是滑膜肉瘤（14.6%）、平滑肌肉瘤（9.5%）、尤因肉瘤（8.6%）和未分化多形性肉瘤（7.7%）。此外，36例患者接受了新辅助化疗。另外22例患者接受了辅助化疗和/或放疗。总生存率为60.56个月，这证明了多学科会诊方法带来了显著改善。所进行的调查表明，使用MDM管理四肢软组织肉瘤可提高患者的生存率。此外，结果证明MDM可能在减少局部复发和转移方面实现最佳治疗。
