Tan Yan, Wang Mina, Yang Ke, Chi Tiange, Liao Zehuan, Wei Peng
School of Traditional Chinese Medicine and School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
Beijing Key Laboratory of Acupuncture Neuromodulation, Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Front Oncol. 2021 Mar 23;11:599995. doi: 10.3389/fonc.2021.599995. eCollection 2021.
Cancer is one of the leading causes of mortality worldwide. PPAR modulators may hold great potential for the management of cancer patients. Indeed, PPARs are critical sensors and regulators of lipid, and they are able to promote eNOS activation, regulate immunity and inflammation response, and affect proliferation and differentiation of cancer cells. Cancer, a name given to a group of diseases, is characterized by multiple distinctive biological behaviors, including angiogenesis, abnormal cell proliferation, aerobic glycolysis, inflammation, etc. In the last decade, emerging evidence has shown that PPAR-α, a nuclear hormone receptor, can modulate carcinogenesis via exerting effects on one or several characteristic pathological behaviors of cancer. Therefore, the multi-functional PPAR modulators have substantial promise in various types of cancer therapies. This review aims to consolidate the functions of PPAR-α, as well as discuss the current and potential applications of PPAR-α agonists and antagonists in tackling cancer.
癌症是全球主要死因之一。过氧化物酶体增殖物激活受体（PPAR）调节剂在癌症患者管理方面可能具有巨大潜力。事实上，PPAR是脂质的关键传感器和调节剂，它们能够促进内皮型一氧化氮合酶（eNOS）激活、调节免疫和炎症反应，并影响癌细胞的增殖和分化。癌症是一组疾病的统称，其特征在于多种独特的生物学行为，包括血管生成、异常细胞增殖、有氧糖酵解、炎症等。在过去十年中，新出现的证据表明，核激素受体PPAR-α可通过对癌症的一种或几种特征性病理行为产生影响来调节致癌作用。因此，多功能PPAR调节剂在各类癌症治疗中具有很大前景。本综述旨在巩固PPAR-α的功能，同时讨论PPAR-α激动剂和拮抗剂在攻克癌症方面的当前及潜在应用。
