Bohringer Christian, Moua Hana, Liu Hong
Department of Anesthesiology and Pain Medicine, University of California Davis Health, Sacramento, California, USA.
Transl Perioper Pain Med. 2019;6(4):129-135. doi: 10.31480/2330-4871/100. Epub 2019 Sep 12.
Succinylcholine is a depolarizing muscle relaxant that has been used for rapid sequence induction and for procedures requiring only a brief duration of muscle relaxation since the late 1950s. The drug, however, has serious side effects and a significant number of contraindications. With the recent introduction of sugammadex in the United States, a drug that can rapidly reverse even large amounts of rocuronium, succinylcholine should no longer be used for endotracheal intubation and its use should be limited to treating acute laryngospasm during episodes of airway obstruction. Given the numerous risks with this drug, and the excellent ablation of airway reflexes with dexmedetomidine, propofol, lidocaine and the larger amounts of rocuronium that can now be administered even for an anesthesia of short duration. The use of succinylcholine for endotracheal intubation should disappear from clinical practice.
琥珀酰胆碱是一种去极化肌肉松弛剂，自20世纪50年代末以来，一直用于快速顺序诱导以及仅需短暂肌肉松弛的手术。然而，该药物有严重的副作用和大量禁忌证。随着舒更葡糖在美国的近期上市，一种甚至能迅速逆转大量罗库溴铵作用的药物，琥珀酰胆碱不应再用于气管插管，其使用应仅限于治疗气道梗阻发作时的急性喉痉挛。鉴于该药物存在诸多风险，以及右美托咪定、丙泊酚、利多卡因能出色地消除气道反射，且现在即使是短时间麻醉也可使用更大剂量的罗库溴铵。琥珀酰胆碱用于气管插管的情况应从临床实践中消失。
