曼诺蝶呤诱导间充质干细胞向神经元样细胞分化。

Mannotriose induced differentiation of mesenchymal stem cells into neuron-like cells.

机构信息

Institute of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 201203 Shanghai, P. R. China.

Fujian Insitute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, 350001 Fuzhou, P. R. China.

出版信息

J Integr Neurosci. 2021 Mar 30;20(1):125-130. doi: 10.31083/j.jin.2021.01.214.

DOI:10.31083/j.jin.2021.01.214

PMID:33834699

Abstract

This article demonstrates that mannotriose effectively induces the differentiation of mesenchymal stem cells into neuron-like cells . Rat-derived mesenchymal stem cells were investigated on their potential to differentiate into neuron-like cells induced by mannotriose purified from . The percentage of the neuron-specific enolase positive cells and the Nissl positive cells after mannotriose treatment was increased. The mRNA levels of neurofilament medium and neuron-specific enolase were upregulated in the mannotriose group compared to the control. These findings demonstrate that mannotriose purified from can effectively induce differentiation of rat-derived mesenchymal stem cells into neuron-like cells.

摘要

本文证明了甘露三糖能有效地诱导间充质干细胞向神经元样细胞分化。研究了从中提取的甘露三糖对大鼠来源的间充质干细胞向神经元样细胞分化的诱导潜能。甘露三糖处理后，神经元特异性烯醇化酶阳性细胞和尼氏小体阳性细胞的比例增加。与对照组相比，甘露三糖组神经丝中间型和神经元特异性烯醇化酶的 mRNA 水平上调。这些发现表明，从中提取的甘露三糖能有效地诱导大鼠来源的间充质干细胞向神经元样细胞分化。