Zhang Lanqiu, Wang Ximo
Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin Nankai Hospital, Tianjin 300100, China. Corresponding author: Wang Ximo, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021 Mar;33(3):360-363. doi: 10.3760/cma.j.cn121430-20200519-00702.
Neutrophils are the most abundant circulating leukocyte type in humans and comprise the host's first line of cellular defense against foreign pathogens invasion. On the other hand, neutrophils are the main mediators of tissue damage induced by acute and chronic inflammation. They were once considered to be short-lived, low transcriptional activity, and terminally differentiated homogeneous leucocytes that failed to return to circulation from tissue. However, more evidence has demonstrated that neutrophils can develop into different sub-populations with phenotypic heterogeneity and functional versatility under physiology and pathological conditions. This review summarizes the phenotypic and functional heterogeneity of neutrophils in sepsis and tumor genesis.
中性粒细胞是人类循环系统中数量最多的白细胞类型，是宿主抵御外来病原体入侵的第一道细胞防线。另一方面，中性粒细胞是急性和慢性炎症诱导组织损伤的主要介质。它们曾被认为是寿命短暂、转录活性低、终末分化的均一性白细胞，无法从组织返回循环系统。然而，越来越多的证据表明，在生理和病理条件下，中性粒细胞可分化为具有表型异质性和功能多样性的不同亚群。本文综述了脓毒症和肿瘤发生过程中中性粒细胞的表型和功能异质性。
