Nachamkin I, Gibson G, Sawyer K, Samel C, Skalina D
University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104-4283.
Diagn Microbiol Infect Dis. 1988 Feb;9(2):87-96. doi: 10.1016/0732-8893(88)90101-0.
Amdinocillin alone and in combination with other beta-lactam antibiotics was tested for in vitro activity against aminoglycoside-susceptible and resistant gram-negative bacteria. Amdinocillin alone or in combination with ampicillin, ticarcillin, piperacillin, cefazolin, cefoxitin, and cefamandole had little to no activity against aminoglycoside-resistant E. coli, E. cloacae, K. pneumoniae, and S. marcescens. There was better activity with aminoglycoside-susceptible organisms, however, Overall, there was significantly more antagonism of amdinocillin combinations when tested with aminoglycoside-resistant organisms than with aminoglycoside-susceptible strains.
对氨曲南单独以及与其他β-内酰胺类抗生素联合使用时，针对氨基糖苷类敏感和耐药革兰氏阴性菌的体外活性进行了测试。氨曲南单独使用或与氨苄西林、替卡西林、哌拉西林、头孢唑林、头孢西丁和头孢孟多联合使用时，对氨基糖苷类耐药的大肠杆菌、阴沟肠杆菌、肺炎克雷伯菌和粘质沙雷氏菌几乎没有活性。然而，对氨基糖苷类敏感菌有较好的活性。总体而言，与氨基糖苷类敏感菌株相比，在与氨基糖苷类耐药菌测试时，氨曲南联合用药的拮抗作用明显更强。
