氨比西林与其他β-内酰胺类抗生素联合对氨基糖苷类敏感和耐药革兰氏阴性菌的体外活性。

In vitro activity of amdinocillin in combination with other beta-lactam antibiotics against aminoglycoside-susceptible and resistant gram-negative bacteria.

作者信息

Nachamkin I, Gibson G, Sawyer K, Samel C, Skalina D

机构信息

University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104-4283.

出版信息

Diagn Microbiol Infect Dis. 1988 Feb;9(2):87-96. doi: 10.1016/0732-8893(88)90101-0.

DOI:10.1016/0732-8893(88)90101-0

Abstract

Amdinocillin alone and in combination with other beta-lactam antibiotics was tested for in vitro activity against aminoglycoside-susceptible and resistant gram-negative bacteria. Amdinocillin alone or in combination with ampicillin, ticarcillin, piperacillin, cefazolin, cefoxitin, and cefamandole had little to no activity against aminoglycoside-resistant E. coli, E. cloacae, K. pneumoniae, and S. marcescens. There was better activity with aminoglycoside-susceptible organisms, however, Overall, there was significantly more antagonism of amdinocillin combinations when tested with aminoglycoside-resistant organisms than with aminoglycoside-susceptible strains.

摘要

对氨曲南单独以及与其他β-内酰胺类抗生素联合使用时，针对氨基糖苷类敏感和耐药革兰氏阴性菌的体外活性进行了测试。氨曲南单独使用或与氨苄西林、替卡西林、哌拉西林、头孢唑林、头孢西丁和头孢孟多联合使用时，对氨基糖苷类耐药的大肠杆菌、阴沟肠杆菌、肺炎克雷伯菌和粘质沙雷氏菌几乎没有活性。然而，对氨基糖苷类敏感菌有较好的活性。总体而言，与氨基糖苷类敏感菌株相比，在与氨基糖苷类耐药菌测试时，氨曲南联合用药的拮抗作用明显更强。

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