Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brasil.
Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brasil.
J Med Virol. 2021 Nov;93(11):6418-6423. doi: 10.1002/jmv.27005. Epub 2021 Jun 21.
The human T-cell lymphotropic virus type-1 (HTLV-1) is associated with severe pathologies, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), adult T-cell leukemia-lymphoma (ATLL), and infective dermatitis associated with the HTLV-1 (IDH). Interestingly, HTLV-1 infection does not necessarily imply the development of pathological processes and it is unknown why some patients remain asymptomatic carriers (AC). Despite some mutations in the HTLV-1 genome appear to influence the outcome of HTLV-1, there are few studies that characterize molecularly the hbz region. This study aimed to perform the molecular characterization of hbz gene isolated from patients with different clinical outcomes. A total of 15 sequences were generated and analyzed with 571 sequences previously published. The analises showed that the R119Q mutation seems to be related to HTLV-1 clinical conditions since the frequency of this HBZ mutation is significantly different in comparison between AC with HAM/TSP and ATLL. The R119Q mutation is possibly a protective factor as the frequency is higher in AC sequences.
人类 T 细胞嗜淋巴细胞病毒 1 型（HTLV-1）与严重的病理有关，如 HTLV-1 相关性脊髓病/热带痉挛性截瘫（HAM/TSP）、成人 T 细胞白血病/淋巴瘤（ATLL）和与 HTLV-1 相关的感染性皮炎（IDH）。有趣的是，HTLV-1 感染并不一定意味着病理过程的发展，目前还不清楚为什么有些患者仍然是无症状携带者（AC）。尽管 HTLV-1 基因组中的一些突变似乎影响 HTLV-1 的结果，但很少有研究对 hbz 区进行分子特征分析。本研究旨在对来自不同临床结果的患者的 hbz 基因进行分子特征分析。共生成了 15 个序列，并与之前发表的 571 个序列进行了分析。分析表明，R119Q 突变似乎与 HTLV-1 的临床状况有关，因为在 AC 与 HAM/TSP 和 ATLL 之间，这种 HBZ 突变的频率有显著差异。R119Q 突变可能是一个保护因素，因为在 AC 序列中频率更高。
