From the Department of Surgery, University of Alabama at Birmingham, Birmingham, AL.
Pancreas. 2021 Mar 1;50(3):347-352. doi: 10.1097/MPA.0000000000001776.
The incidence of pancreatic neuroendocrine tumors (PNETs) has increased over the last decade. Black patients have worse survival outcomes. This study investigates whether oncologic outcomes are racially disparate at a single institution.
Retrospective analysis was performed on 151 patients with resected PNETs between 2010 and 2019.
More White males and Black females presented with PNETs (P = 0.02). White patients were older (65 years vs 60 years; P = 0.03), more likely to be married (P < 0.01), and had higher median estimated yearly incomes ($28,973 vs $17,767; P < 0.01) than Black patients. Overall and disease-free survival were not different. Black patients had larger median tumor sizes (30 mm vs 23 mm; P = 0.02). Tumor size was predictive of recurrence only for White patients (hazard ratio, 1.02; P = 0.01). Collectively, tumors greater than 20 mm in size were more likely to have recurrence (P = 0.048), but this cutoff was not predictive in either racial cohort independently.
Black patients undergoing curative resection of PNETs at our institution presented with larger tumors, but that increased size is not predictive of disease-free survival in this population.
过去十年间，胰腺神经内分泌肿瘤（PNETs）的发病率有所上升。黑人患者的生存结局更差。本研究旨在调查在单一机构中，肿瘤学结局是否存在种族差异。
对 2010 年至 2019 年间接受切除治疗的 151 例 PNET 患者进行回顾性分析。
更多白人男性和黑人女性患有 PNET（P=0.02）。白人患者年龄更大（65 岁 vs 60 岁；P=0.03）、更有可能已婚（P＜0.01）、中位估计年收入更高（$28973 美元 vs $17767 美元；P＜0.01）。总体生存和无病生存无差异。黑人患者的肿瘤中位数更大（30 毫米 vs 23 毫米；P=0.02）。肿瘤大小仅对白人患者的复发具有预测性（风险比，1.02；P=0.01）。总的来说，大于 20 毫米的肿瘤更有可能复发（P=0.048），但这一截值在两个种族队列中均无独立预测性。
在本机构接受 PNET 根治性切除术的黑人患者肿瘤更大，但肿瘤大小的增加并不能预测该人群的无病生存。
