F-18 氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描对导管内乳头状黏液性肿瘤特征的诊断作用：一项更新的系统评价和荟萃分析。

Diagnostic Role of F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Characterization of Intraductal Papillary Mucinous Neoplasms: An Updated Systematic Review and Meta-analysis.

机构信息

From the Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital.

出版信息

Pancreas. 2021 Mar 1;50(3):353-361. doi: 10.1097/MPA.0000000000001760.

DOI:10.1097/MPA.0000000000001760

PMID:33835966

Abstract

OBJECTIVES

The purpose of the current study was to investigate the diagnostic performance of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) or PET/computed tomography (CT) for characterization of intraductal papillary mucinous neoplasms (IPMN) through a systematic review and meta-analysis.

METHODS

The PubMed and Embase database were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT for characterization of IPMN.

RESULTS

Across 14 studies (752 patients), the pooled sensitivity for F-18 FDG PET or PET/CT was 0.84 (95% confidence interval [CI], 0.77-0.89) with heterogeneity (I2 = 55.5, P = 0.01) and a pooled specificity of 0.95 (95% CI, 0.88-0.98) with heterogeneity (I2 = 83.9, P < 0.001). Likelihood ratio (LR) syntheses gave an overall positive likelihood ratio (LR+) of 17.4 (95% CI, 6.5-46.8) and negative likelihood ratio (LR-) of 0.17 (95% CI, 0.12-0.25). The pooled diagnostic odds ratio was 101 (95% CI, 31-327). Hierarchical summary receiver operating characteristic curve and indicates that the areas under the curve were 0.93 (95% CI, 0.90-0.95).

CONCLUSIONS

The current meta-analysis showed a high sensitivity, specificity, diagnostic odds ratio, and the LR scatter gram of F-18 FDG PET or PET/CT for determination of characteristics of IPMN.

摘要

目的

本研究旨在通过系统评价和荟萃分析，探讨 18F 氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）或 PET/计算机断层扫描（CT）对胰腺导管内乳头状黏液性肿瘤（IPMN）进行特征描述的诊断性能。

方法

在 PubMed 和 Embase 数据库中搜索评估 18F FDG PET 或 PET/CT 对 IPMN 特征描述的诊断性能的研究。

结果

在 14 项研究（752 例患者）中，18F FDG PET 或 PET/CT 的汇总敏感性为 0.84（95%置信区间 [CI]，0.77-0.89），存在异质性（I2=55.5，P=0.01），汇总特异性为 0.95（95%CI，0.88-0.98），存在异质性（I2=83.9，P<0.001）。似然比（LR）综合分析得出总体阳性似然比（LR+）为 17.4（95%CI，6.5-46.8），阴性似然比（LR-）为 0.17（95%CI，0.12-0.25）。汇总诊断优势比为 101（95%CI，31-327）。分层汇总受试者工作特征曲线表明，曲线下面积为 0.93（95%CI，0.90-0.95）。