Wang Liang, Xu Dan, Cai Longbiao, Dai Jia, Li Yirong, Xu Haibo
Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, China.
Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan University, China.
Curr Res Transl Med. 2021 May;69(2):103274. doi: 10.1016/j.retram.2020.103274. Epub 2021 Apr 6.
Signal Transducer and Activator of Transcription (STAT) belongs to the acyltransferase family and participates in cell viability response to different cell stimuli and pathogens. By mediating the expression of a variety of genes, the STAT family plays a prominent part in mammal immunity, proliferation and differentiation. Dysregulations and mutations of STAT factors have been revealed in many kinds of cancers including diffuse gliomas; however, expression characteristic and prognostic value of STAT in diffuse gliomas remain to be elucidated. In this study, we analyzed the transcriptional and survival data of gliomas using ONCOMINE, cBioPortal, GEPIA, COXPRESDB and WEBGESTALTR databases. The results demonstrated that the transcriptional level of STAT1, STAT3 and STAT5A in gliomas was significantly higher than that in normal tissue. Furthermore, dysregulations of STAT1, STAT3, STAT4, STAT5B and STAT6 were referred to as the potential biomarkers to sub-group analysis of gliomas. Survival analysis by the Kaplan-Meier Plotter suggested that glioma patients with high expression of STAT1, STAT3 and STAT5B tended to have poor survival. These data revealed that the STAT family may be an essential aspect of glioma progression and prognosis.
信号转导子和转录激活子（STAT）属于酰基转移酶家族，参与细胞对不同细胞刺激和病原体的生存反应。通过介导多种基因的表达，STAT家族在哺乳动物免疫、增殖和分化中发挥着重要作用。在包括弥漫性胶质瘤在内的多种癌症中均发现了STAT因子的失调和突变；然而，STAT在弥漫性胶质瘤中的表达特征和预后价值仍有待阐明。在本研究中，我们使用ONCOMINE、cBioPortal、GEPIA、COXPRESDB和WEBGESTALTR数据库分析了胶质瘤的转录和生存数据。结果表明，胶质瘤中STAT1、STAT3和STAT5A的转录水平显著高于正常组织。此外，STAT1、STAT3、STAT4、STAT5B和STAT6的失调被认为是胶质瘤亚组分析的潜在生物标志物。Kaplan-Meier Plotter进行的生存分析表明，STAT1、STAT3和STAT5B高表达的胶质瘤患者往往生存较差。这些数据表明，STAT家族可能是胶质瘤进展和预后的一个重要方面。
